Journal: eBioMedicine

Article Title: Significance of integrated clinical and proteomic characteristics analysis for pathogenesis and management of Crohn's disease with concomitant psoriasis

doi: 10.1016/j.ebiom.2025.105981

Figure Lengend Snippet: Prediction of CDPS and the correlation between proteomics and clinical characteristics. A . Heatmap of the correlation among expression of co-expression protein modules, expression of CDPS key proteins and clinical characteristics (IFX, response to infliximab; UST, response to ustekinumab; PS, psoriasis; NEUT, neutrophils; CRP, C-reactive protein; WBC, white blood cell; ESR, erythrocyte sedimentation rate; ALB, albumin; SES-CD, simple endoscopic score for Crohn's Disease); ∗ p < 0.05, ∗∗ p < 0.01, ∗∗∗ p < 0.001. B . Heatmap of correlation between immune cell infiltration and expression of co-expression modules and CDPS key proteins; ∗ p < 0.05, ∗∗ p < 0.01, ∗∗∗ p < 0.001. C . Box plot of expression of co-expression modules in response (R) and non-response (NR) group (UST, ustekinumab; IFX, infliximab); UST (NR) n = 6, UST (R) n = 11; IFX (NR) n = 13, IFX (R) n = 6, Wilcoxon rank-sum test, ∗ p < 0.05, ∗∗ p < 0.01, ∗∗∗ p < 0.001. D . Box plot of level of immune cells infiltration in response (R) and non-response (NR) group (UST: ustekinumab; IFX, infliximab); UST (NR) n = 6, UST (R) n = 11; IFX (NR) n = 13, IFX (R) n = 6, Wilcoxon rank-sum test, ∗ p < 0.05, ∗∗ p < 0.01, ∗∗∗ p < 0.001. E . Heatmap of correlation between immune cells infiltration and each of the following: response to ustekinumab, response to infliximab, and the occurrence of psoriasis (IFX, response to infliximab; UST, response to ustekinumab; PS, psoriasis); ∗ p < 0.05, ∗∗ p < 0.01, ∗∗∗ p < 0.001. F . ROC curves of prediction models (validation group) for the likelihood of achieving an endoscopic response by intestinal mucosa proteomics; activated CD8 T cell AUC: 0.675 (95% CI: 0.333–1.000), turquoise AUC: 0.750 (95% CI: 0.500–1.000), multi-omics model AUC: 0.830 (95% CI: 0.500–1.000). G . ROC curves of prediction models (validation group) for the likelihood of achieving an endoscopic response by body fluids proteomics; HGFAC (plasma) AUC: 0.780 (95% CI: 0.333–1.000), HGFAC (urine) AUC: 0.780 (95% CI: 0.333–1.000), multi-omics model AUC: 0.830 (95% CI: 0.500–1.000). H . ROC curves of prediction models (validation group) for likelihood of the development of CDPS constructed using selected features by lasso regression; turquoise AUC: 0.960 (95% CI: 0.750–1.000), KRT7 AUC: 0.622 (95% CI: 0.333–1.000), HGFAC (plasma) AUC: 0.750 (95% CI: 0.500–1.000), multi-omics model AUC: 0.830 (95% CI: 0.500–1.000).

Article Snippet: Feature selection for the faecal proteomics data was performed using the least absolute shrinkage and selection operator (LASSO) logistic regression model.

Techniques: Expressing, Sedimentation, Biomarker Discovery, Clinical Proteomics, Construct